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  • 25 mg - 103 EUR
  • 100 mg - 309 EUR
  • 250 mg - 618 EUR

Dasatinib

Dasatinib is a dual Src/Abl kinase inhibitor with potent antitumor activity. In addition to inhibiting the wild-type BCR-ABL, dasatinib inhibited 14 of 15 BCR-ABL mutants. It is a potent inhibitor of all members of the Src family, including c-Src, Lck, Fyn, and Yes (IC50 < 1.1 nmol/L).

catalogue number: D027
synonyms: BMS-354825, Sprycel
CAS: 302962-49-8
MW: 488.01 g/mol

References
J Med Chem. 2004 Dec 30;47(27):6658-61. PMID: 15615512
BioDrugs. 2011 Jun 1;25(3):147-57. PMID: 21528941
Crystal Structure of Dasatinib Bound to ABL Kinase PDB: 2GQG
Crystal Structure of Dasatinib Bound to c-KIT PDB: 3G5D