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  • 25 mg - 22 EUR
  • 100 mg - 65 EUR
  • 250 mg - 130 EUR

Cisplatin

Cisplatin is an anticancer drug used to treat various types of cancers, including sarcomas, small cell lung cancer, ovarian cancer, lymphomas, and germ cell tumors. In cells, one of the chloride ligands is slowly displaced by water. This allows the platinum atom to bind to bases of DNA; it has a particularly high affinity for guanine. Cisplatin crosslinks DNA and thus interferes with its replication and cell division. This DNA damage triggers DNA repair mechanisms, which initiate apoptosis when repair proves impossible.

catalogue number: C118
synonyms: cisplatinum, cis-diamminedichloroplatinum(II), CDDP, Platinol, Platinol-AQ
CAS: 15663-27-1
MW: 300.05 g/mol

References
Anticancer Agents Med Chem. 2007 Jan;7(1):3-18. PMID: 17266502
Vet Comp Oncol. 2008 Mar;6(1):1-18. PMID: 19178659