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  • 5 mg - 97 EUR
  • 25 mg - 388 EUR
  • 100 mg - 1164 EUR

CYT387

CYT387 is a potent inhibitor of the JAK1 and JAK2 kinases (IC50=11 and 18 nM, respectively) that is significantly less active against other kinases, including JAK3 (IC50=155 nM). CYT387 caused growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines, while nonhematopoietic cell lines were unaffected. It is being developed to treat myeloproliferative neoplasms/disorders.

catalogue number: C101
synonyms: CYT 11387, Cyt-387
CAS: 1056634-68-4
MW: 414.47 g/mol

References
Leukemia. 2009 Aug;23(8):1441-5. PMID: 19295546
Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92. PMID: 19762238
Blood. 2010 Jun 24;115(25):5232-40. PMID: 20385788