Alphabetical listing of all products

A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

Prices
  • 5 mg - 140 EUR
  • 25 mg - 560 EUR
  • 100 mg - 1680 EUR

Cediranib

Cediranib is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of KDR tyrosine kinase. Concordant with this activity, it inhibits VEGF-stimulated proliferation and KDR phosphorylation in human umbilical vein endothelial cells with IC50 values of 0.4 and 0.5 nmol/L, respectively. In a fibroblast/endothelial cell co-culture model for vessel sprouting, Cediranib also reduced vessel area, length, and branching at subnanomolar concentrations.

catalogue number: C099
synonyms: AZD2171
CAS: 288383-20-0
MW: 450.51 g/mol

References
Cancer Res. 2005 May 15;65(10):4389-400. PMID: 15899831