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  • 5 mg - 53 EUR
  • 25 mg - 220 EUR
  • 100 mg - 660 EUR

CHIR-258

CHIR-258 is an orally bioavailable, inhibitor of VEGFR-2, FGFR-1, and PDGFRbeta, with IC50 values of <0.1 microM against these kinases. It is in phase III development for the treatment of renal cell carcinoma, and in phase II development as a treatment for advanced breast cancer, relapsed multiple myeloma and urothelial cancer.

catalogue number: C039
synonyms: Dovitinib, TKI258
CAS: 915769-50-5
MW: 500.53 g/mol

References
Blood. 2005 Apr 1;105(7):2941-8. PMID: 15598814
J Med Chem. 2009 Jan 22;52(2):278-92. PMID: 19113866