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CHIR-99021

CHIR-99021 is a glycogen synthase kinase 3b (GSK3b) inhibitor with an IC50 value of 7 nM. It does not exhibit cross-reactivity against CDKs and is reported to have a 350-fold selectivity toward GSK3b. CHIR-99021 inhibits cellular proliferation with an IC50 value of about 10 microM.

catalogue number: C038
synonyms: CT99021
CAS: 252917-06-9
MW: 465.34 g/mol

References
Diabetes. 2003 Mar;52(3):588-95. PMID: 12606497