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  • 5 mg - 98 EUR
  • 25 mg - 392 EUR
  • 100 mg - 1176 EUR

CVT313

CVT-313 is a potent and selective CDK2 inhibitor with an IC50 of 0.5 microM in vitro. Its IC50 against CDK4 is 215 microM while those against MAPK, PKA, and PKC are > 1.25 mM; it has no effect on other, non-related ATP-dependent serine/threonine kinases. In cells exposed to CVT-313, hyperphosphorylation of the retinoblastoma gene product was inhibited, and progression through the cell cycle was arrested at the G1/S boundary. CVT-313 also inhibits CDC5L.

catalogue number: C024
synonyms: -
CAS: 199986-75-9
MW: 400.47 g/mol

References
J Biol Chem. 1997 Nov 14;272(46):29207-11. PMID: 9360999
Cell Cycle. 2007 Dec 1;6(23):2982-9. PMID: 18156799
Cell Cycle. 2008 Jun 15;7(12):1795-803. PMID: 18583928