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  • 5 mg - 85 EUR
  • 25 mg - 340 EUR
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Crizotinib

Crizotinib is an orally bioavailable, ATP-competitive, potent and selective dual inhibitor of the c-MET and ALK kinases. It has been particularly effective against anaplastic large cell lymphoma and non-small cell lung cancer (NSCLC) cell lines harboring ALK translocations that cause the expression of oncogenic ALK fusion proteins.

catalogue number: C023
synonyms: PF-02341066
CAS: 877399-52-5
MW: 450.34 g/mol

References
Curr Opin Investig Drugs. 2010 Dec;11(12):1477-90. PMID: 21154129
J Med Chem. 2011 Sep 22;54(18):6342-63. PMID: 21812414
Crystal structure of the PF-02341066/c-MET complex PDB: 2wgj
Crystal structure of the PF-02341066/ALK complex PDB: 2xp2