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Bleomycin (sulfate)

Bleomycin is a glycopeptide antibiotic produced by Streptomyces verticillus and used in the treatment of Hodgkin lymphoma, squamous cell carcinomas, testicular cancer, pleurodesis and plantar warts. It is commonly thought to exert its biological effects as a metallodrug, which causes oxidative DNA damage. Bleomycin induces dioxygen activation and sequence-selective degradation of DNA and also mediates the oxidative degradation of all major classes of cellular RNA. The oxidation-reduction pathways involved in the reactions of iron-bleomycin, copper-bleomycin, and other metal-bleomycin species with O2 have been examined, and the complexes' photochemical activation has been studied.

catalogue number: B115
synonyms: Blenoxane
CAS: 9041-93-4
MW: 1512.62 g/mol (sulfate)

References
Chem Biol Interact. 1990;73(2-3):133-82. PMID: 1690086
J Nat Prod. 2000 Jan;63(1):158-68. PMID: 10650103