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  • 25 mg - 70 EUR
  • 100 mg - 210 EUR
  • 250 mg - 420 EUR

Dactolisib (BEZ235)

Dactolisib is an imidazo[4,5-c]quinoline derivative that competitively inhibits the PI3K and mTOR kinases, efficiently and selectively preventing dysfunctional activation of the PI3K pathway and thereby inducing G(1) arrest. It has an IC50 value of 4 nM against the p110a isoform of PI3K, 75 nM against the p110b isoform, 7 nM against the p110d isoform and 5 nM against the p110g isoform.

catalogue number: B017
synonyms: NVP-BEZ235
CAS: 915019-65-7
MW: 469.55 g/mol

References
Mol Cancer Ther. 2008 Jul;7(7):1851-63. PMID: 18606717
Cancer Res. 2008 Oct 1;68(19):8022-30. PMID: 18829560
Cancer Res. 2008 Nov 15;68(22):9221-30. PMID: 19010894