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  • 5 mg - 74 EUR
  • 25 mg - 296 EUR
  • 100 mg - 888 EUR

Belinostat

Belinostat was found to inhibit in vitro cancer cell growth with sub- to low micromolar IC50 potency. It also exhibited synergistic activity when used in combination with certain chemotherapeutics and effectively inhibited the growth of multidrug-resistant cells. Belinostat is a hydroxamate-type inhibitor of histone deacetylase (HDAC) that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM and induces a concentration-dependent (0.2-5 microM) increase in acetylation of histone H4 in tumor cell lines.

catalogue number: B016
synonyms: PX105684,PXD101
CAS: 414864-00-9
MW: 318.35 g/mol

References
Mol Cancer Ther. 2003 Aug;2(8):721-8. PMID: 12939461
Mol Cancer Ther. 2006 Aug;5(8):2086-95. PMID: 16928830