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  • 5 mg - 120 EUR
  • 25 mg - 480 EUR
  • 100 mg - 1440 EUR

Alectinib (hydrochloride)

Alectinib is potent, selective, and orally available ALK inhibitor (IC50 value of 1.9 nM) showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. It inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth.

catalogue number: A174
synonyms: CH5424802, AF802
CAS: 1256589-74-8
MW: 519.08 g/mol

Cancer Cell. 2011 May 17;19(5):679-90. PMID: 21575866
Bioorg Med Chem. 2012 Feb 1;20(3):1271-80. PMID: 22225917