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  • 5 mg - 165 EUR
  • 25 mg - 660 EUR
  • 100 mg - 1980 EUR

Apatinib mesylate

Apatinib is an orally bioavailable tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2/KDR) with IC50 value of 2.4 nM. Inhibition of this important pro-angiogenic receptor blocks VEGF-mediated endothelial cell migration and proliferation that in turn reduces new blood vessel formation in tumor tissue. It is being developed as a potential targeted treatment for metastatic gastric carcinoma, metastatic breast cancer and advanced hepatocellular carcinoma.

catalogue number: A111
synonyms: YN968D1
CAS: 1218779-75-9
MW: 493.58 g/mol (mesylate)

Cancer Res. 2010 Oct 15;70(20):7981-91. PMID: 20876799
Cancer Sci. 2011 Jul;102(7):1374-80. PMID: 21443688