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  • 5 mg - 74 EUR
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AZD8055

AZD8055 is a potent, selective, and orally bioavailable mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. It is an ATP-competitive inhibitor of mTOR kinase activity, with an IC50 of 0.8 nmol/L. AZD8055 showed excellent selectivity (approximately 1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family. Moreover, it exhibited no significant activity against a panel of 260 kinases at concentrations of up to 10 micromol/L. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as that of the mTORC2 substrate AKT and downstream proteins.

catalogue number: A015
synonyms: -
CAS: 1009298-09-2
MW: 465.54 g/mol

References
Cancer Res. 2010 Jan 1;70(1):288-98. PMID: 20028854