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  • 5 mg - 88 EUR
  • 25 mg - 352 EUR
  • 100 mg - 1056 EUR

AZD5438

AZD5438 is a potent inhibitor of cyclin-dependent kinases (CDKs) 1, 2, and 9 (IC50, 16, 6, and 20 nmol/L, respectively). It exhibits significant in vitro antiproliferative activity in human tumor cell lines (with IC(50) values ranging from 0.2-1.7 micromol/L), inhibiting the phosphorylation of CDK substrates including pRb, nucleolin, protein phosphatase 1a, and the carboxy-termiinal domain of RNA polymerase II. In this way, it blocks cell cycle progression in the G(2)-M, S, and G(1) phases. It is currently undergoing clinical trials as an anticancer drug.

catalogue number: A014
synonyms: -
CAS: 602306-29-6
MW: 371.46 g/mol

References
Mol Cancer Ther. 2009 Jul;8(7):1856-66. PMID: 19509270