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  • 5 mg - 98 EUR
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Aminopurvalanol is a potent cyclin-dependent kinase inhibitor; it has IC50 values of 33 nM for Cdk1/cyclin B, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35. Aminopurvalanol-treated cells acquired phenotypic characteristics of differentiated macrophages and underwent cell cycle with a 4N DNA content. Affinity chromatography and biochemical reconstitution experiments indicated that it targets cyclin-dependent kinase 1 (CDK1).

catalogue number: A011
CAS: 220792-57-4
MW: 403.91 g/mol

J Med Chem. 2006 Jun 29;49(13):3826-31. PMID: 10220373
X-ray structure of human CDK6-V cyclin with the inhibitor aminopurvalanol 2F2C