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  • 5 mg - 74 EUR
  • 25 mg - 296 EUR
  • 100 mg - 888 EUR

ABT-888

ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 with K(i)s of 5.2 and 2.9 nmol/L, respectively. The compound has good oral bioavailability and crosses the blood-brain barrier. ABT-888 strongly potentiated temozolomide in the B16F10 s.c. murine melanoma model.

catalogue number: A007
synonyms: Veliparib
CAS: 912444-00-9
MW: 244.29 g/mol

References
Clin Cancer Res. 2007 May 1;13(9):2728-37. PMID: 17473206
Crystal structure of PARP fragment with ABT-888 3KJD