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Prices
  • 5 mg - 148 EUR
  • 25 mg - 592 EUR
  • 100 mg - 1776 EUR

ABT-737

ABT-737 is a small-molecule inhibitor of protein-protein interactions that primarily affects the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w. Rather than directly initiating the apoptotic process, it enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 improves survival, causes regression of established tumours, and produces cures in a high percentage of tested mice.

catalogue number: A006
CAS: 852808-04-9
MW: 813.43 g/mol

References
Nature. 2005 Jun 2;435(7042):677-81. PMID: 15902208
Cell Death Differ. 2007 Sep;14(9):1711-3. PMID: 17572662
Crystal structure of Bcl-xL in complex with ABT-737 2YXJ