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  • 5 mg - 148 EUR
  • 25 mg - 592 EUR
  • 100 mg - 1776 EUR

Navitoclax (ABT-263)

ABT-263 is a potent and orally bioavailable Bcl-2 family inhibitor. It disrupts interactions between Bcl-2/Bcl-xL and pro-death proteins (e.g., Bim), leading to the initiation of apoptosis. In human tumor cells, ABT-263 induces Bax translocation, cytochrome c release, and subsequent apoptosis.

catalogue number: A005
synonyms: Navitoclax
CAS: 923564-51-6
MW: 974.61 g/mol

References
Cancer Res. 2008 May 1;68(9):3421-8. PMID: 18451170