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A-966492

A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, it is orally bioavailable, crosses the blood-brain barrier, and appears to distribute into tumor tissue.

catalogue number: A004
synonyms: 22b
CAS: 934162-61-5
MW: 324.35 g/mol

References
J Med Chem. 2010 Apr 22;53(8):3142-53. PMID: 20337371